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タイトル: | Modeling cell proliferation for simulating three-dimensional tissue morphogenesis based on a reversible network reconnection framework |
著者: | Okuda, Satoru Inoue, Yasuhiro https://orcid.org/0000-0002-1968-8883 (unconfirmed) Eiraku, Mototsugu Sasai, Yoshiki Adachi, Taiji https://orcid.org/0000-0001-5280-4156 (unconfirmed) |
著者名の別形: | 井上, 康博 安達, 泰治 |
キーワード: | Tissue morphogenesis Cell proliferation Cell division Multicellular dynamics Three-dimensional vertex model Reversible network reconnection model Computational biomechanics Developmental biomechanics |
発行日: | Oct-2013 |
出版者: | Springer Nature |
誌名: | Biomechanics and Modeling in Mechanobiology |
巻: | 12 |
号: | 5 |
開始ページ: | 987 |
終了ページ: | 996 |
抄録: | Tissue morphogenesis in multicellular organisms is accompanied by proliferative cell behaviors: cell division (increase in cell number after each cell cycle) and cell growth (increase in cell volume during each cell cycle). These proliferative cell behaviors can be regulated by multicellular dynamics to achieve proper tissue sizes and shapes in three-dimensional (3D) space. To analyze multicellular dynamics, a reversible network reconnection (RNR) model has been suggested, in which each cell shape is expressed by a single polyhedron. In this study, to apply the RNR model to simulate tissue morphogenesis involving proliferative cell behaviors, we model cell proliferation based on a RNR model framework. In this model, cell division was expressed by dividing a polyhedron at a planar surface for which cell division behaviors were characterized by three quantities: timing, intracellular position, and normal direction of the dividing plane. In addition, cell growth was expressed by volume growth as a function of individual cell times within their respective cell cycles. Numerical simulations using the proposed model showed that tissues grew during successive cell divisions with several cell cycle times. During these processes, the cell number in tissues increased while maintaining individual cell size and shape. Furthermore, tissue morphology dramatically changed based on different regulations of cell division directions. Thus, the proposed model successfully provided a basis for expressing proliferative cell behaviors during morphogenesis based on a RNR model framework. |
著作権等: | This is a post-peer-review, pre-copyedit version of an article published in 'Biomechanics and Modeling in Mechanobiology'. The final authenticated version is available online at: https://doi.org/10.1007/s10237-012-0458-8. The full-text file will be made open to the public on 30 November 2013 in accordance with publisher's 'Terms and Conditions for Self-Archiving'. This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
URI: | http://hdl.handle.net/2433/274886 |
DOI(出版社版): | 10.1007/s10237-012-0458-8 |
PubMed ID: | 23196700 |
出現コレクション: | 学術雑誌掲載論文等 |
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