Evaluation of hematuria and proteinuria positivity in relation to ageing in 6,651 apparently healthy men and women

Abstract

We examined the positivity of hematuria and proteinuria in relation to ageing in 6, 651 apparently healthy persons (2, 556 women and 4, 095 men) who underwent multiphasic health screening in our Medical Checkup Center. Commercially available dipsticks were used. The time from urine collection to dipstick analysis was within 60 minutes. The mean age of women was 48.2 years (range 10 to 82) and that of men was 49.9 years (range 7 to 89). Approximately 30.1, 1.5, and 0.7% of the women had hematuria, proteinuria, and hematoproteinuria, respectively; and 11.4, 4.0, 1.5% of the men had the corresponding urine abnormalities, respectively. Hematuria was 2.6 times more common in women than in men, and proteinuria was 2.7 times more common in men than in women. The positivity of hematuria increased linearly with age in women (Rs = 0.943, P = 0.0350). On the other hand, the positivity of proteinuria or hematoproteinuria was not correlated with age (P = 0.8386 and P = 0.0639, respectively). In men, the positivity of hematuria or hematoproteinuria was not correlated with age (P = 0.0845 and P = 0.0845, respectively). However, the positivity of proteinuria in those more than 30-year age group increased linearly with age (Rs = 1.000, P = 0.0455). The true meaning of such gender- and/or age-related differences in urinary abnormalities remains to be determined.

健康診断のために当院健診センターを訪れ, 尿潜血と蛋白尿のスクリーニング検査を受けた男女6, 651人(女性:2, 556人, 男性:4, 095人)を対象に, 加齢に伴う両所見の陽性頻度の検討を行った。市販の尿試験紙法を用いて行い, 採尿から試験紙法の判定までは60分以内とした。女性の平均年齢は48.2歳(10～82歳)であり, 男性は49.9歳(7～89歳)であった。女性の30.1, 1.5そして0.7%, また男性の11.4, 4.0そして1.5%が, それぞれ尿潜血, 蛋白尿, 血蛋白尿陽性所見を有していた。尿潜血陽性率は男性に比べ女性で2.6倍高く, 逆に蛋白尿陽性率は男性で2.7倍高かった。尿潜血陽性率は女性においては加齢とともに増加したが(Rs=0.943, P=0.0350), 蛋白尿や血蛋白尿陽性率は加齢との関連性は認められなかった(P=0.8386およびP=0.0639)。一方, 男性においては尿潜血および血蛋白尿陽性率と加齢との間には何ら関連性が認められなかったが(P=0.0845およびP=0.0845), 30歳以上の男性では加齢とともに蛋白尿陽性率は有意に増加した(Rs=1.000, P=0.0455)。性や加齢に関連したこれら尿異常所見の真の意味を探るためにも, 今後のさらなる検討が必要であると思われた。(著者抄録)