尿中酵素パターンによる腎腫瘍の鑑別診断

Abstract

Up to the present time urinary enzymology has meant measuring the activity of single or a few enzymes out of collected urine. Its diagnostic value is small and is satisfactory only as a screening test. The diagnostic value of a urinary enzyme pattern was examined in renal tumors. After carefully selecting elements of the enzyme pattern we observed an important shift of relative proportions of single enzyme within the assayed pattern. This permitted, for the first time in urinary enzymology, a diagnosis. Such a shift of proportions has not been previously identified in man. Therefore we suggested the determination of a "direct enzyme" pattern. This has been defined and its advantages are as follows: 1.close correlation with the investigated pathological lesion. 2. No influence from other areas of the urogenital system. 3. Usual normal values and urinary collection are not necessary. The ideal form of urinary enzymology in man is diagnosis by an enzyme pattern from voided urine. Therefore it is necessary to demonstrate in future the correlation between tissue pattern and corresponding urinary enzyme pattern under identical conditions.