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Title: APOBEC3B can impair genomic stability by inducing base substitutions in genomic DNA in human cells
Authors: Shinohara, Masanobu
Io, Katsuhiro
Shindo, Keisuke
Matsui, Masashi
Sakamoto, Takashi
Tada, Kohei
Kobayashi, Masayuki
Kadowaki, Norimitsu
Takaori-Kondo, Akifumi
Author's alias: 新堂, 啓祐
Keywords: Cancer genomics
DNA damage and repair
Haematological cancer
Oncogenes
Issue Date: 13-Nov-2012
Publisher: Nature Publishing Group
Journal title: Scientific Reports
Volume: 2
Thesis number: 806
DOI: 10.1038/srep00806
Abstract: Human APOBEC3 proteins play pivotal roles in intracellular defense against viral infection by catalyzing deamination of cytidine residues, leading to base substitutions in viral DNA. Activation-induced cytidine deaminase (AID), another member of the APOBEC family, is capable of editing immunoglobulin (Ig) and non-Ig genes, and aberrant expression of AID leads to tumorigenesis. However, it remains unclear whether APOBEC3 (A3) proteins affect stability of human genome. Here we demonstrate that both A3A and A3B can induce base substitutions into human genome as AID can. A3B is highly expressed in several lymphoma cells and somatic mutations occur in some oncogenes of the cells highly expressing A3B. Furthermore, transfection of A3B gene into lymphoma cells induces base substitutions incMYC gene. These data suggest that aberrant expression of A3B can evoke genomic instability by inducing base substitutions into human genome, which might lead to tumorigenesis in human cells.
Description: 新規発癌遺伝子アポベック3による新たな発癌機構. 京都大学プレスリリース. 2012-11-14.
Rights: This work is licensed under a Creative Commons Attribution-NonCommercial-ShareALike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/
URI: http://hdl.handle.net/2433/161297
Related Link: http://www.kyoto-u.ac.jp/ja/news_data/h/h1/news6/2012/121106_1.htm
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