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ファイル | 記述 | サイズ | フォーマット | |
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B978-0-12-417158-9.00015-7.pdf | 343.75 kB | Adobe PDF | 見る/開く |
タイトル: | Phospholipid scrambling on the plasma membrane. |
著者: | Suzuki, Jun Nagata, Shigekazu |
著者名の別形: | 長田, 重一 |
キーワード: | Phospholipid Phosphatidylserine Phosphatidylcholine Scramblase Xkr8 TMEM16F |
発行日: | 2014 |
出版者: | Elsevier Inc. |
誌名: | Methods in enzymology |
巻: | 544 |
開始ページ: | 381 |
終了ページ: | 393 |
抄録: | Phospholipids are asymmetrically distributed at plasma membrane in normal cells, and scrambled in various biological situations such as blood clotting and apoptotic cell death. Recent studies revealed that phospholipid scrambling is mediated by at least two independent mechanisms. An eight transmembrane-containing protein TMEM16F Ca(2+)-dependently promotes the phospholipid scrambling, which is required for the PS exposure in activated platelets during blood clotting. On the other hand, a six transmembrane-containing protein Xk-related family protein 8 is activated by caspases during apoptosis and promotes the phospholipid scrambling, thus exposing PS as an "eat-me-signal." In this chapter, we describe procedures for assaying phospholipid scrambling. |
記述: | Regulated Cell Death Part A: Apoptotic Mechanisms |
著作権等: | © 2014 Elsevier Inc. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 This is not the published version. Please cite only the published version. |
URI: | http://hdl.handle.net/2433/189103 |
DOI(出版社版): | 10.1016/B978-0-12-417158-9.00015-7 |
PubMed ID: | 24974298 |
出現コレクション: | 学術雑誌掲載論文等 |
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