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タイトル: | Recovery of photoreceptor outer segments after anti-VEGF therapy for age-related macular degeneration. |
著者: | Oishi, Akio https://orcid.org/0000-0002-0977-9458 (unconfirmed) Shimozono, Masataka Mandai, Michiko Hata, Masayuki Nishida, Akihiro Kurimoto, Yasuo |
著者名の別形: | 大石, 明生 |
キーワード: | Age-related macular degeneration Optical coherence tomography Inner segment/outer segment junction External limiting membrane |
発行日: | Feb-2013 |
出版者: | Springer-Verlag |
誌名: | Graefe's archive for clinical and experimental ophthalmology |
巻: | 251 |
号: | 2 |
開始ページ: | 435 |
終了ページ: | 440 |
抄録: | [Purpose]To evaluate whether the status of the external limiting membrane (ELM) or inner segment/outer segment junction (IS/OS) improves after intravitreal injection of ranibizumab for age-related macular degeneration (AMD). We also evaluated whether the pre-operative values of these parameters are associated with the visual prognosis. [Methods]This was a hospital-based, cross-sectional study. Seventy-six eyes of 76 treatment-naive AMD patients who received three monthly intravitreal injections of ranibizumab followed for more than 6 months with additional as-needed injections were investigated. Spectral domain OCT was used to evaluate the length of ELM, IS/OS, and foveal thickness pre- and post-operatively. Changes of ELM and IS/OS length were evaluated postoperatively. Correlation coefficients between pre-operative parameters and post-operative visual acuity were also analyzed. [Results]Significant changes were noted in mean logMAR (0.66 to 0.53), foveal thickness (231.1 to 151.1 μm), and IS/OS length (514.9 to 832.3 μm) after the treatment. ELM length did not improve significantly (1,312.4 to 1,376.7 μm). Restoration of IS/OS occured where ELM is retained. Although pre-operative ELM length, IS/OS length, and foveal thickness showed correlation with post-operative logMAR (R=-0.51, -0.39, and 0.46, respectively), the most powerful predictive factor for visual prognosis was pre-operative logMAR (R=0.77, p<0.001). [Conclusions] IS/OS status improves in response to anti-VEGF therapy but ELM seems to have less plasticity. The status of IS/OS and ELM can be used as prognostic factors but the predictive power is inferior to that of baseline visual acuity. |
著作権等: | The final publication is available at Springer via http://dx.doi.org/10.1007/s00417-012-2034-4 This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
URI: | http://hdl.handle.net/2433/189745 |
DOI(出版社版): | 10.1007/s00417-012-2034-4 |
PubMed ID: | 22576370 |
出現コレクション: | 学術雑誌掲載論文等 |
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