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19466315.2014.1003090.pdf | 730.47 kB | Adobe PDF | 見る/開く |
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DCフィールド | 値 | 言語 |
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dc.contributor.author | Hamasaki, Toshimitsu | en |
dc.contributor.author | Asakura, Koko | en |
dc.contributor.author | Evans, Scott R | en |
dc.contributor.author | Sugimoto, Tomoyuki | en |
dc.contributor.author | Sozu, Takashi | en |
dc.contributor.alternative | 寒水, 孝司 | ja |
dc.date.accessioned | 2015-06-29T02:05:34Z | - |
dc.date.available | 2015-06-29T02:05:34Z | - |
dc.date.issued | 2015-03-18 | - |
dc.identifier.issn | 1946-6315 | - |
dc.identifier.uri | http://hdl.handle.net/2433/198576 | - |
dc.description.abstract | We discuss the decision-making frameworks for clinical trials with multiple co-primary endpoints in a group-sequential setting. The decision-making frameworks can account for flexibilities such as a varying number of analyses, equally or unequally spaced increments of information and fixed or adaptive Type I error allocation among endpoints. The frameworks can provide efficiency, i.e., potentially fewer trial participants, than the fixed sample size designs. We investigate the operating characteristics of the decision-making frameworks and provide guidance on constructing efficient group-sequential strategies in clinical trials with multiple co-primary endpoints. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Taylor & Francis Group | en |
dc.rights | This is an Accepted Manuscript of an article published by Taylor & Francis Group in Statistics in Biopharmaceutical Research on 18/03/2015, available online: http://www.tandfonline.com/10.1080/19466315.2014.1003090. | en |
dc.rights | 許諾条件により本文ファイルは2016-03-18に公開. | ja |
dc.rights | This is not the published version. Please cite only the published version. | en |
dc.rights | この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 | ja |
dc.subject | Adaptive Type I error allocation | en |
dc.subject | Average sample number | en |
dc.subject | Equally or unequally spaced increments of information | en |
dc.subject | Hierarchical testing procedure | en |
dc.subject | Maximum sample size | en |
dc.title | Group-Sequential Strategies in Clinical Trials with Multiple Co-Primary Outcomes. | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Statistics in biopharmaceutical research | en |
dc.identifier.volume | 7 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 36 | - |
dc.identifier.epage | 54 | - |
dc.relation.doi | 10.1080/19466315.2014.1003090 | - |
dc.textversion | author | - |
dc.startdate.bitstreamsavailable | 2016-03-18 | - |
dc.identifier.pmid | 25844122 | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
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