ダウンロード数: 359
このアイテムのファイル:
ファイル | 記述 | サイズ | フォーマット | |
---|---|---|---|---|
c4py01346h.pdf | 940.41 kB | Adobe PDF | 見る/開く |
完全メタデータレコード
DCフィールド | 値 | 言語 |
---|---|---|
dc.contributor.author | Koda, Yuta | en |
dc.contributor.author | Terashima, Takaya | en |
dc.contributor.author | Sawamoto, Mitsuo | en |
dc.contributor.author | Maynard, Heather D. | en |
dc.contributor.alternative | 寺島, 崇矢 | ja |
dc.date.accessioned | 2015-07-10T06:04:36Z | - |
dc.date.available | 2015-07-10T06:04:36Z | - |
dc.date.issued | 2015-10-23 | - |
dc.identifier.issn | 1759-9954 | - |
dc.identifier.uri | http://hdl.handle.net/2433/198730 | - |
dc.description | Accepted 22 Oct 2014. | en |
dc.description.abstract | Herein, amphiphilic/fluorous random copolymers bearing poly(ethylene glycol) (PEG) chains and perfluorinated alkane pendants were developed as novel non-cytotoxic polymers for protein conjugation. Three kinds of random copolymers with different initiating terminals (carboxylic acid, pyridyl disulfide, and N-hydroxysuccinimide ester) were prepared by reversible addition–fragmentation chain transfer (RAFT) copolymerization of a PEG methyl ether methacrylate and a perfluorinated alkane methacrylate with the corresponding functional chain transfer agents. All of the polymers were soluble in water to form nanostructures with perfluorinated compartments via fluorous interaction: large aggregates from the intermolecular multi-chain association and compact unimer micelles from the intramolecular single-chain folding. Such a PEGylated and perfluorinated random copolymer was non-cytotoxic to NIH 3T3 mouse embryonic fibroblast cells and human umbilical vein endothelial cells (HUVECs). Additionally, a random copolymer with a pyridyl disulfide terminal was also successfully conjugated with a thiolated lysozyme. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Royal Society of Chemistry | en |
dc.rights | This journal is © The Royal Society of Chemistry. | en |
dc.rights | 許諾条件により本文ファイルは2015-10-22に公開. | ja |
dc.rights | This is not the published version. Please cite only the published version. | en |
dc.rights | この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 | ja |
dc.title | Amphiphilic/fluorous random copolymers as a new class of non-cytotoxic polymeric materials for protein conjugation | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Polymer Chemistry | en |
dc.identifier.volume | 6 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | 240 | - |
dc.identifier.epage | 247 | - |
dc.relation.doi | 10.1039/C4PY01346H | - |
dc.textversion | author | - |
dc.startdate.bitstreamsavailable | 2015-10-22 | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
このリポジトリに保管されているアイテムはすべて著作権により保護されています。