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| ファイル | 記述 | サイズ | フォーマット | |
|---|---|---|---|---|
| j.critrevonc.2014.10.002.pdf | 227.09 kB | Adobe PDF | 見る/開く |
| タイトル: | Evaluation of serum-based cancer biomarkers: a brief review from a clinical and computational viewpoint. |
| 著者: | Yotsukura, Sohiya Mamitsuka, Hiroshi    https://orcid.org/0000-0002-6607-5617 (unconfirmed) |
| 著者名の別形: | 四倉, 聡妃弥 |
| キーワード: | Serum biomarkers Quantitative assessment Computational evaluation Predictive values Likelihood ratios Receiver operating characteristic curve Diagnostic odds ratio |
| 発行日: | 14-Oct-2014 |
| 出版者: | Elsevier Ireland Ltd. |
| 誌名: | Critical reviews in oncology/hematology |
| 巻: | 93 |
| 号: | 2 |
| 開始ページ: | 103 |
| 終了ページ: | 115 |
| 抄録: | Biomarkers are vital to detect diseases in various clinical stages. A variety of cancer serum biomarkers are already known, while for more accurate cancer-type detection, there required more rigorous evaluation manners, especially computational evaluation measures, for biomarkers. In this review, we first show three typical pitfalls in finding biomarkers and their examples, after briefly presenting standard five clinical biomarker screening phases by National Cancer Institute. We then introduce current computational biomarker evaluation measures, including current, standard methods with their intrinsic features. We further show an up-to-date list of existing cancer serum biomarkers, pointing out several issues, being caused by the limitations of current biomarker evaluation approaches. Finally we discuss the current attempts to develop new, statistically robust, computational serum-based biomarker measures in terms of specificity to each of various cancer types. |
| 著作権等: | © 2014 Elsevier Ireland Ltd. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/. NOTICE: this is the author's version of a work that was accepted for publication in <Critical Reviews in Oncology/Hematology>. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in [Critical Reviews in Oncology/Hematology, Volume 93, Issue 2, Pages 103–115] doi:10.1016/j.critrevonc.2014.10.002. 許諾条件により本文ファイルは2015-10-14に公開. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 This is not the published version. Please cite only the published version. |
| URI: | http://hdl.handle.net/2433/198771 |
| DOI(出版社版): | 10.1016/j.critrevonc.2014.10.002 |
| PubMed ID: | 25459666 |
| 出現コレクション: | 学術雑誌掲載論文等 |
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