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タイトル: | Regio- and stereoselective multisubstituted olefin synthesis via hydro/carboalumination of alkynes and subsequent iron-catalysed cross-coupling reaction with alkyl halides |
著者: | Kawamura, Shintaro Agata, Ryosuke Nakamura, Masaharu https://orcid.org/0000-0002-1419-2117 (unconfirmed) |
著者名の別形: | 中村, 正治 |
発行日: | 19-Jul-2015 |
出版者: | Royal Society of Chemistry |
誌名: | Organic Chemistry Frontiers |
巻: | 2 |
号: | 9 |
開始ページ: | 1053 |
終了ページ: | 1058 |
抄録: | A new synthetic route towards multisubstituted olefins, which are recurring core units in various pharmaceutical and bioactive compounds, was developed based on the direct cross coupling of alkenylaluminium reagents which were prepared in situ by the hydro- and carbometalation of alkynes, with non-activated alkyl halides in the presence of an iron catalyst. For the first time, alkenylaluminium reagents participated in an iron-catalysed cross-coupling reaction, following the activation of the aluminium reagents by a metal fluoride. The hydro- and carboalumination of alkynes and the subsequent cross-coupling reactions could be conducted in a one-pot manner and proceeded regio- and stereoselectively to give a variety of di-, tri-, and tetrasubstituted alkenes in good to excellent yields. |
記述: | This article is part of themed collection: Celebrating the 80th Birthday of Professor Ei-ichi Negishi. |
著作権等: | This journal is © the Partner Organisations 2015. The full-text file will be made open to the public on 17 June 2016 in accordance with publisher's 'Terms and Conditions for Self-Archiving'. This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
URI: | http://hdl.handle.net/2433/199702 |
DOI(出版社版): | 10.1039/C5QO00147A |
出現コレクション: | 学術雑誌掲載論文等 |
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