ダウンロード数: 250
このアイテムのファイル:
ファイル | 記述 | サイズ | フォーマット | |
---|---|---|---|---|
lt.23884.pdf | 1.9 MB | Adobe PDF | 見る/開く |
タイトル: | Hepatoprotective effect by pretreatment with olprinone in a swine partial hepatectomy model. |
著者: | Iguchi, Kohta Hatano, Etsuro Yamanaka, Kenya Sato, Motohiko Yamamoto, Gen Kasai, Yosuke Okamoto, Tatsuya Okuno, Masayuki Taura, Kojiro Fukumoto, Kyoko Ueno, Kazuyuki Uemoto, Shinji |
著者名の別形: | 波多野, 悦朗 |
発行日: | Jul-2014 |
出版者: | wiley |
誌名: | Liver transplantation |
巻: | 20 |
号: | 7 |
開始ページ: | 838 |
終了ページ: | 849 |
抄録: | Excessive portal flow to a small remnant liver or small-for-size graft is a primary factor of small-for-size syndrome. We demonstrated that olprinone (OLP), a phosphodiesterase III inhibitor, had a hepatoprotective effect in a rat extended hepatectomy model and a small-for-size liver transplantation model through a modification of the portal venous pressure (PVP). To identify the appropriate dose and duration of treatment for clinical applications, we conducted experiments with a swine partial hepatectomy model. Twenty microminipigs were divided into 4 groups that received the following treatments: (A) saline (control group), (B) OLP at 0.3 μg/kg/minute (preoperative and postoperative administration), (C) OLP at 0.1 μg/kg/minute (preoperative administration), and (D) OLP at 0.3 μg/kg/minute (preoperative administration). The pigs underwent 70% partial hepatectomy. Hemodynamic changes, including changes in PVP, were examined. Liver biopsy was performed 1 and 3 hours after hepatectomy. Blood samples were collected until postoperative day 7 (POD7). In comparison with group A, PVP elevations, periportal edema, and sinusoidal hemorrhaging were attenuated after left Glisson's ligation in groups C and D. Pretreatment with OLP in groups C and D preserved the microstructure of sinusoids and improved the prothrombin activity 1 and 3 hours after hepatectomy. These animals showed better recovery of the remnant liver volume and the plasma disappearance rate of indocyanine green on POD7. In contrast, group B showed exacerbation of liver damage. Measurements of the serum OLP concentration showed that 10 ng/mL OLP was appropriate for a hepatoprotective effect. In conclusion, pretreatment with OLP shows hepatoprotective effects in a swine partial hepatectomy model. OLP may have the potential to ameliorate patients' outcomes after hepatectomy or liver transplantation. |
著作権等: | This is the peer reviewed version of the following article: Iguchi, K., Hatano, E., Yamanaka, K., Sato, M., Yamamoto, G., Kasai, Y., Okamoto, T., Okuno, M., Taura, K., Fukumoto, K., Ueno, K. and Uemoto, S. (2014), Hepatoprotective effect by pretreatment with olprinone in a swine partial hepatectomy model. Liver Transpl, 20: 838–849, which has been published in final form at http://dx.doi.org/10.1002/lt.23884. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
URI: | http://hdl.handle.net/2433/199896 |
DOI(出版社版): | 10.1002/lt.23884 |
PubMed ID: | 24700629 |
出現コレクション: | 学術雑誌掲載論文等 |
このリポジトリに保管されているアイテムはすべて著作権により保護されています。