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dc.contributor.author | Okuda, Hiroshi | en |
dc.contributor.author | Kanai, Akinori | en |
dc.contributor.author | Ito, Shinji | en |
dc.contributor.author | Matsui, Hirotaka | en |
dc.contributor.author | Yokoyama, Akihiko | en |
dc.contributor.alternative | 奥田, 博史 | ja |
dc.contributor.alternative | 横山, 明彦 | ja |
dc.date.accessioned | 2015-11-25T04:12:16Z | - |
dc.date.available | 2015-11-25T04:12:16Z | - |
dc.date.issued | 2015-11-23 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | http://hdl.handle.net/2433/201896 | - |
dc.description | 難治性の白血病が発症するメカニズムの解明に成功 -新たな創薬に期待-. 京都大学プレスリリース. 2015-11-24. | ja |
dc.description.abstract | Gene rearrangements generate MLL fusion genes, which can lead to aggressive leukemia. In most cases, MLL fuses with a gene encoding a component of the AEP (AF4 family/ENL family/P-TEFb) coactivator complex. MLL–AEP fusion proteins constitutively activate their target genes to immortalize haematopoietic progenitors. Here we show that AEP and MLL–AEP fusion proteins activate transcription through selectivity factor 1 (SL1), a core component of the pre-initiation complex (PIC) of RNA polymerase I (RNAP1). The pSER domain of AF4 family proteins associates with SL1 on chromatin and loads TATA-binding protein (TBP) onto the promoter to initiate RNA polymerase II (RNAP2)-dependent transcription. These results reveal a previously unknown transcription initiation mechanism involving AEP and a role for SL1 as a TBP-loading factor in RNAP2-dependent gene activation. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Publishing Group | en |
dc.rights | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ | en |
dc.subject | Biological sciences | en |
dc.subject | Cancer | en |
dc.subject | Molecular biology | en |
dc.title | AF4 uses the SL1 components of RNAP1 machinery to initiate MLL fusion- and AEP-dependent transcription | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Nature Communications | en |
dc.identifier.volume | 6 | - |
dc.relation.doi | 10.1038/ncomms9869 | - |
dc.textversion | publisher | - |
dc.identifier.artnum | 8869 | - |
dc.identifier.pmid | 26593443 | - |
dc.relation.url | https://www.kyoto-u.ac.jp/ja/research-news/2015-11-24 | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
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