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dc.contributor.author | Miyake, Yuka | en |
dc.contributor.author | Ishikawa, Syungo | en |
dc.contributor.author | Kimura, Yu | en |
dc.contributor.author | Son, Aoi | en |
dc.contributor.author | Imai, Hirohiko | en |
dc.contributor.author | Matsuda, Tetsuya | en |
dc.contributor.author | Yamada, Hisatsugu | en |
dc.contributor.author | Toshimitsu, Akio | en |
dc.contributor.author | Kondo, Teruyuki | en |
dc.contributor.alternative | 木村, 祐 | ja |
dc.contributor.alternative | 今井, 宏彦 | ja |
dc.contributor.alternative | 松田, 哲也 | ja |
dc.contributor.alternative | 近藤, 輝幸 | ja |
dc.date.accessioned | 2016-05-16T02:53:04Z | - |
dc.date.available | 2016-05-16T02:53:04Z | - |
dc.date.issued | 2015-12-18 | - |
dc.identifier.issn | 1424-8220 | - |
dc.identifier.uri | http://hdl.handle.net/2433/210694 | - |
dc.description.abstract | Recently, we developed novel chiral dendrimer-triamine-coordinated Gd-MRI contrast agents (Gd-MRI CAs), which showed longitudinal relaxivity (r1) values about four times higher than that of clinically used Gd-DTPA (Magnevist®, Bayer). In our continuing study of pharmacokinetic differences derived from both the chirality and generation of Gd-MRI CAs, we found that the ability of chiral dendrimer Gd-MRI CAs to circulate within the body can be directly evaluated by in vitro MRI (7 T). In this study, the association constants (Ka) of chiral dendrimer Gd-MRI CAs to bovine serum albumin (BSA), measured and calculated with a quartz crystal microbalance (QCM) in vitro, were found to be an extremely easy means for evaluating the body-circulation ability of chiral dendrimer Gd-MRI CAs. The Ka values of S-isomeric dendrimer Gd-MRI CAs were generally greater than those of R-isomeric dendrimer Gd-MRI CAs, which is consistent with the results of our previous MRI study in vivo. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | MDPI AG | en |
dc.rights | © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). | en |
dc.subject | chiral dendrimer | en |
dc.subject | gadolinium | en |
dc.subject | contrast agent | en |
dc.subject | magnetic resonance imaging (MRI) | en |
dc.subject | quartz crystal microbalance (QCM) | en |
dc.subject | association constant (Ka) | en |
dc.title | Pharmacokinetics of chiral dendrimer-triamine-coordinated Gd-MRI contrast agents evaluated by in Vivo MRI and estimated by in Vitro QCM | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Sensors | en |
dc.identifier.volume | 15 | - |
dc.identifier.issue | 12 | - |
dc.identifier.spage | 31973 | - |
dc.identifier.epage | 31986 | - |
dc.relation.doi | 10.3390/s151229900 | - |
dc.textversion | publisher | - |
dc.identifier.pmid | 26694418 | - |
dcterms.accessRights | open access | - |
dc.identifier.eissn | 1424-8220 | - |
出現コレクション: | 学術雑誌掲載論文等 |
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