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タイトル: | Relationship between duration of illness and cardiac autonomic nervous activity in anorexia nervosa |
著者: | Nakai, Yoshikatsu Fujita, Masatoshi Nin, Kazuko https://orcid.org/0000-0003-4720-6420 (unconfirmed) Noma, Shun'ichi Teramukai, Satoshi |
著者名の別形: | 任, 和子 野間, 俊一 |
キーワード: | Anorexia nervosa Heart rate variability Low-frequency power High-frequency power Cardiac autonomic nervous activity |
発行日: | 23-Apr-2015 |
出版者: | BioMed Central Ltd. |
誌名: | BioPsychoSocial Medicine |
巻: | 9 |
論文番号: | 12 |
抄録: | Background: The mortality rate associated with anorexia nervosa (AN) is high, and death is mainly attributable to cardiac events. A wide range of autonomic nervous system disturbances may be mechanisms underlying the increased cardiovascular mortality and sudden death of patients with AN. Heart rate variability (HRV) has been proven to be a reliable noninvasive method for quantitative assessment of sympathetic and parasympathetic regulation of heart rate (HR). The longer the duration of illness of AN patients, the higher the mortality rate. However, there have been few reports on the relationship between the duration of illness and HRV in AN. Hence, the aims of this study were to compare the cardiac autonomic nervous activity (CANA) of female patients with AN and age-matched female controls and to evaluate the relationship between the duration of illness and the CANA of the AN patients. Methods: We studied 14 female patients with AN and 22 age-matched healthy women. Beat-to-beat heart rate variability, recorded in a supine position, was investigated using power spectral analysis. Result: Mean heart rate was positively correlated with normalized high-frequency (HF: 0.15 to 0.40Hz) power and negatively correlated with the low-frequency (LF: 0.04 to 0.15Hz)/HF power (LF/HF) ratio of the controls. On the other hand, duration of illness was negatively correlated with normalized HF power and positively correlated with the LF/HF ratio of the AN patients. Conclusions: These results suggest that, given that the LF/HF ratio is an estimate of cardiac sympathovagal balance, anorectic patients with a long illness duration display lower vagal tone (parasympathetic withdrawal) and high sympathetic tone. |
著作権等: | © Nakai et al.; licensee BioMed Central. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. |
URI: | http://hdl.handle.net/2433/213948 |
DOI(出版社版): | 10.1186/s13030-015-0032-6 |
PubMed ID: | 25908939 |
出現コレクション: | 学術雑誌掲載論文等 |
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