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タイトル: | Theta oscillation and neuronal activity in rat hippocampus are involved in temporal discrimination of time in seconds |
著者: | Nakazono, Tomoaki Sano, Tomomi Takahashi, Susumu Sakurai, Yoshio |
著者名の別形: | 中園, 智晶 |
キーワード: | time perception time cell theta oscillation hippocampus duration discrimination |
発行日: | 22-Jun-2015 |
出版者: | Frontiers Media SA |
誌名: | Frontiers in Systems Neuroscience |
巻: | 9 |
論文番号: | 95 |
抄録: | The discovery of time cells revealed that the rodent hippocampus has information regarding time. Previous studies have suggested that the role of hippocampal time cells is to integrate temporally segregated events into a sequence using working memory with time perception. However, it is unclear whether hippocampal cells contribute to time perception itself because most previous studies employed delayed matching-to-sample tasks that did not separately evaluate time perception from working memory processes. Here, we investigated the function of the rat hippocampus in time perception using a temporal discrimination task. In the task, rats had to discriminate between durations of 1 and 3 s to get a reward, and maintaining task-related information as working memory was not required. We found that some hippocampal neurons showed firing rate modulation similar to that of time cells. Moreover, theta oscillation of local field potentials (LFPs) showed a transient enhancement of power during time discrimination periods. However, there were little relationships between the neuronal activities and theta oscillations. These results suggest that both the individual neuronal activities and theta oscillations of LFPs in the hippocampus have a possibility to be engaged in seconds order time perception; however, they participate in different ways. |
著作権等: | © 2015 Nakazono, Sano, Takahashi and Sakurai. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
URI: | http://hdl.handle.net/2433/214312 |
DOI(出版社版): | 10.3389/fnsys.2015.00095 |
PubMed ID: | 26157367 |
出現コレクション: | 学術雑誌掲載論文等 |
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