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タイトル: | The Deficiency of indoleamine 2,3-Dioxygenase aggravates the CCl4 -Induced liver fibrosis in mice |
著者: | Ogiso, Hideyuki Ito, Hiroyasu Ando, Tatsuya Arioka, Yuko Kanbe, Ayumu Ando, Kazuki Ishikawa, Tetsuya Saito, Kuniaki Hara, Akira Moriwaki, Hisataka Shimizu, Masahito Seishima, Mitsuru |
著者名の別形: | 斉藤, 邦明 |
発行日: | 6-Sep-2016 |
出版者: | Public Library of Science |
誌名: | PLOS ONE |
巻: | 11 |
号: | 9 |
論文番号: | e0162183 |
抄録: | In the present study, we examined the role of indoleamine 2, 3-dioxygenase (IDO) in the development of CCl4 -induced hepatic fibrosis. The liver fibrosis induced by repetitive administration with CCl4 was aggravated in IDO-KO mice compared to WT mice. In IDO-KO mice treated with CCl4 , the number of several inflammatory cells and the expression of proinflammatory cytokines increased in the liver. In the results, activated hepatic stellate cells (HSCs) and fibrogenic factors on HSCs increased after repetitive CCl4 administration in IDO-KO mice compared to WT mice. Moreover, the treatment with L-tryptophan aggravated the CCl4 -induced hepatic fibrosis in WT mice. Our findings demonstrated that the IDO deficiency enhanced the inflammation in the liver and aggravated liver fibrosis in repetitive CCl4 -treated mice. |
著作権等: | © 2016 Ogiso et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
URI: | http://hdl.handle.net/2433/217097 |
DOI(出版社版): | 10.1371/journal.pone.0162183 |
PubMed ID: | 27598994 |
出現コレクション: | 学術雑誌掲載論文等 |
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