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タイトル: | Shifting transcriptional machinery is required for long-term memory maintenance and modification in Drosophila mushroom bodies |
著者: | Hirano, Yukinori Ihara, Kunio Masuda, Tomoko Yamamoto, Takuya https://orcid.org/0000-0002-0022-3947 (unconfirmed) Iwata, Ikuko Takahashi, Aya Awata, Hiroko Nakamura, Naosuke Takakura, Mai Suzuki, Yusuke https://orcid.org/0000-0002-5379-4030 (unconfirmed) Horiuchi, Junjiro Okuno, Hiroyuki Saitoe, Minoru |
著者名の別形: | 平野, 恭敬 |
発行日: | 14-Nov-2016 |
出版者: | Springer Nature |
誌名: | Nature Communications |
巻: | 7 |
論文番号: | 13471 |
抄録: | Accumulating evidence suggests that transcriptional regulation is required for maintenance of long-term memories (LTMs). Here we characterize global transcriptional and epigenetic changes that occur during LTM storage in the Drosophila mushroom bodies (MBs), structures important for memory. Although LTM formation requires the CREB transcription factor and its coactivator, CBP, subsequent early maintenance requires CREB and a different coactivator, CRTC. Late maintenance becomes CREB independent and instead requires the transcription factor Bx. Bx expression initially depends on CREB/CRTC activity, but later becomes CREB/CRTC independent. The timing of the CREB/CRTC early maintenance phase correlates with the time window for LTM extinction and we identify different subsets of CREB/CRTC target genes that are required for memory maintenance and extinction. Furthermore, we find that prolonging CREB/CRTC-dependent transcription extends the time window for LTM extinction. Our results demonstrate the dynamic nature of stored memory and its regulation by shifting transcription systems in the MBs. |
著作権等: | © Author(s) 2016. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
URI: | http://hdl.handle.net/2433/217556 |
DOI(出版社版): | 10.1038/ncomms13471 |
PubMed ID: | 27841260 |
出現コレクション: | 学術雑誌掲載論文等 |
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