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タイトル: | Cleaved form of osteopontin in urine as a clinical marker of lupus nephritis |
著者: | Kitagori, Koji Yoshifuji, Hajime https://orcid.org/0000-0001-7082-4900 (unconfirmed) Oku, Takuma Sasaki, Chiyomi Miyata, Hitomi Mori, Keita P. Nakajima, Toshiki Ohmura, Koichiro Kawabata, Daisuke Yukawa, Naoichiro Imura, Yoshitaka Murakami, Kosaku https://orcid.org/0000-0001-5981-4648 (unconfirmed) Nakashima, Ran Usui, Takashi Fujii, Takao Sakai, Kaoru Yanagita, Motoko Hirayama, Yoshitaka Mimori, Tsuneyo |
著者名の別形: | 吉藤, 元 宮田, 仁美 大村, 浩一郎 湯川, 尚一郎 井村, 嘉孝 藤井, 隆夫 柳田, 素子 三森, 経世 |
発行日: | 19-Dec-2016 |
出版者: | Public Library of Science |
誌名: | PLOS ONE |
巻: | 11 |
号: | 12 |
論文番号: | e0167141 |
抄録: | We assessed the utility of two forms of osteopontin (OPN), OPN full and its cleaved form (OPN N-half), in plasma and urine as markers of disease activity in lupus nephritis (LN). Samples were collected from patients with systemic lupus erythematosus (SLE) (LN: N = 29, non- LN: N = 27), IgA nephropathy (IgAN) (N = 14), minimal change nephrotic syndrome (MCNS) (N = 5), diabetic nephropathy (DN) (N = 14) and healthy volunteers (HC) (N = 17). While there was no significant difference in urine OPN full concentration between groups, urine OPN N-half concentration was significantly higher in patients with LN than HC (p < 0.05). Moreover, urine OPN N-half was higher in LN patients with overt proteinuria (urine protein/ creatinine ratio: P/C > 0.5) than LN patients with minimal proteinuria (P/C < 0.5, p < 0.0001), and also higher than in DN patients with overt proteinuria (P/C > 0.5, p < 0.01). Urine thrombin activity correlated with urine OPN N-half concentration (p < 0.0001), but not with urine OPN full concentration. These results suggest that urine OPN N-half concentration reflects renal inflammation. Thus, urine OPN N-half may be a novel disease activity marker for LN. |
著作権等: | © 2016 Kitagori et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
URI: | http://hdl.handle.net/2433/217828 |
DOI(出版社版): | 10.1371/journal.pone.0167141 |
PubMed ID: | 27992535 |
出現コレクション: | 学術雑誌掲載論文等 |
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