ダウンロード数: 133
このアイテムのファイル:
ファイル | 記述 | サイズ | フォーマット | |
---|---|---|---|---|
rcr2.206.pdf | 24.2 MB | Adobe PDF | 見る/開く |
タイトル: | Concomitant T790M mutation and small-cell lung cancer transformation after acquired resistance to epidermal growth factor receptor-tyrosine kinase inhibitor |
著者: | Fujita, Kohei Kim, Young Hak Yoshizawa, Akihiko Mio, Tadashi Mishima, Michiaki |
著者名の別形: | 金, 永学 吉澤, 明彦 三嶋, 理晃 |
キーワード: | Adenocarcinoma Epidermal growth factor receptor-tyrosine kinase inhibitor Small-cell lung cancer transformation T790M mutation |
発行日: | 1-Jan-2017 |
出版者: | Wiley-Blackwell Publishing Ltd |
誌名: | Respirology Case Reports |
巻: | 5 |
号: | 1 |
論文番号: | e00206 |
抄録: | A 70-year-old man was admitted to our hospital with an abnormal chest X-ray shadow. Bronchoscopy revealed an adenocarcinoma tumour with an epidermal growth factor receptor (EGFR) exon 19 deletion. Positron emission tomography-computed tomography scanning and magnetic resonance imaging showed advanced stage IV lung cancer. He was treated with erlotinib as a first-line drug, which maintained a clinical response for 16 months. After disease progression, a re-biopsy was done from the tumour in the right lower lobe. The obtained specimen harboured both small-cell lung cancer (SCLC) transformation with retention of the EGFR 19 deletion and the development of an EGFR T790M mutation. We came across a very rare condition of concomitant T790M mutation and SCLC transformation after acquired resistance to EGFR-tyrosine kinase inhibitor. |
著作権等: | © 2017 Asian Pacific Society of Respirology. |
URI: | http://hdl.handle.net/2433/218320 |
DOI(出版社版): | 10.1002/rcr2.206 |
PubMed ID: | 28031840 |
出現コレクション: | 学術雑誌掲載論文等 |
このリポジトリに保管されているアイテムはすべて著作権により保護されています。