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タイトル: | Visualization of tumor-related blood vessels in human breast by photoacoustic imaging system with a hemispherical detector array |
著者: | Toi, M. Asao, Y. Matsumoto, Y. Sekiguchi, H. Yoshikawa, A. Takada, M. Kataoka, M. Endo, T. Kawaguchi-Sakita, N. Kawashima, M. Fakhrejahani, E. Kanao, S. Yamaga, I. Nakayama, Y. Tokiwa, M. Torii, M. Yagi, T. Sakurai, T. Togashi, K. Shiina, T. |
著者名の別形: | 戸井, 雅和 髙田, 正泰 川島, 雅央 FAKHREJAHANI, ELHAM 鳥井, 雅恵 松本, 純明 川口, 展子 桜井, 孝規 椎名, 毅 金尾, 昌太郎 関口, 博之 片岡, 正子 |
発行日: | 7-Feb-2017 |
出版者: | Nature Publishing Group |
誌名: | Scientific Reports |
巻: | 7 |
論文番号: | 41970 |
抄録: | Noninvasive measurement of the distribution and oxygenation state of hemoglobin (Hb) inside the tissue is strongly required to analyze the tumor-associated vasculatures. We developed a photoacoustic imaging (PAI) system with a hemispherical-shaped detector array (HDA). Here, we show that PAI system with HDA revealed finer vasculature, more detailed blood-vessel branching structures, and more detailed morphological vessel characteristics compared with MRI by the use of breast shape deformation of MRI to PAI and their fused image. Morphologically abnormal peritumoral blood vessel features, including centripetal photoacoustic signals and disruption or narrowing of vessel signals, were observed and intratumoral signals were detected by PAI in breast cancer tissues as a result of the clinical study of 22 malignant cases. Interestingly, it was also possible to analyze anticancer treatment-driven changes in vascular morphological features and function, such as improvement of intratumoral blood perfusion and relevant changes in intravascular hemoglobin saturation of oxygen. This clinical study indicated that PAI appears to be a promising tool for noninvasive analysis of human blood vessels and may contribute to improve cancer diagnosis. |
著作権等: | © The Author(s) 2017. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
URI: | http://hdl.handle.net/2433/218405 |
DOI(出版社版): | 10.1038/srep41970 |
PubMed ID: | 28169313 |
出現コレクション: | 学術雑誌掲載論文等 |
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