IFNα を含めた集学的治療が奏功した進行性腎細胞癌の1例

Abstract

A 55-year-old man was admitted with cough and sputum. Computed tomography revealed a left renal tumor, 7 cm in diameter, and multiple lung tumors with left pleural effusion. We considered nephrectomy impossible given his poor performance status. He received 500 × 104 IU/day of interferon alpha subcutaneously three times a week. Five months after the start of interferon alpha therapy, the renal and lung tumors were markedly reduced in size. Because of improvement of his condition and downsizing of tumors, radical nephrectomy was performed. In addition, interferon alpha therapy was continued for seven more months. At that point, all metastatic pulmonary lesions but one had disappeared. Interferon alpha therapy was then continued for one more year. About five years after the first admission, he is alive without evidence of disease.