前立腺肥大症に關する研究 第III篇:尿中酸フォスファターゼに関する臨床的研究

Abstract

1)諸種泌尿器疾患々者80例に就てその尿中A.P.L.を測定した結果, 前立腺肥大症或は前立腺癌に於ても健康人に比し平均して特に高値を示すと言う事は無く, その他の疾患に於ても略々健康人の値と等しい値を示したが, 前立腺結核, 血精液症, 去勢術を行つた者等に於ては明かに低値を示した.2)男子の尿中酸フォス?アターゼも大量投与すればAndrcgenによつて増加しEstrogenによつて減少する.然しその効果は一時的であり, 薬剤の投与を中止すれば治療前の値に復帰するものであつて永続性は認め・られない.3)レントゲン深部治療, インテレニンの注射, 睾丸移植等によつては尿中A.P.Lに殆んど変動を認めない.4)性ホルモン剤投与による尿中A.P.L.の変動には疾患の種類によつて差異は認められないが, 同じ前立腺肥大症或は癌に於ても性ホルモンに非常に敏感なものと余り反応しないものとが存在する.5) 一血清A.P.Lbと尿中A.P.L.とは常に必ずしも平行しない.(文献は最終篇に一括して掲載)投与すればAndrcgenによつて増加しEstrogenによつて減少する.然しその効果は一時的であり, 薬剤の投与を中止すれば治療前の値に復帰するものであつて永続性は認め・られない.3)レントゲン深部治療, インテレニンの注射, 睾丸移植等によつては尿中A.P.Lに殆んど変動を認めない.4)性ホルモン剤投与による尿中A.P.L.の変動には疾患の種類によつて差異は認められないが, 同じ前立腺肥大症或は癌に於ても性ホルモンに非常に敏感なものと余り反応しないものとが存在する.5) 一血清A.P.Lbと尿中A.P.L.とは常に必ずしも平行しない.

1. Urinary acid phosphatase of 80 patients with uro-genital diseases was measured. The results were as follows; The average of the urinary acid phosphatase level in the patients with benign prostatic hyperplasia and carcinoma of the prostate did not show any clinically significant difference compared with the level in the normal adult male. Also, no other differences were observed in other diseases except in tuberculosis of the prostate gland, haemospermiasis, or previously castrated patients. All these showed markedly low urinary acid phosphatase level. 2. The urinary acid phosphatase increased when androgen was administered by 1M-route, but it decreased when estrogen was administered. These changes were temporary and were especially more distinct in castrated patients. 3. The urinary acid phosphatase was not affected by deep x-ray therapy and the injection of "Interenin" (which is one of the adrenocortical hormone preparations), or by the transplantation of testes. 4. The degree of change in urinary acid phosphatase due to the administration of sexual hormone preparations showed minimal difference in various diseases. Even in the same disease, however, i. e. in benign prostatic hyperplasia or carcinoma of the prostate, one can find considerable difference in the sensitivity to the administration of sexual hormones. Then, it seems that in the patient whose urinary acid phosphatase level is easily affected by the sexual hormones, his clinical symptoms improve on hormonal treatment. But, in the patient whose urinary acid phosphatase level is hardly affected by sexual hormones, his clinical symptoms show no noticeable changes. 5. No correlation between the serum acid phosphatase level and the urinary acid phosphatase level has been recognized.