腎孟に於ける抗生物質の吸収に就て

Abstract

When penicillin and streptomycin solution were instillated to the renal pelvis of rabbits, they were good absorbed on the renal pelvis and were transferred into blood on the groups of the knotted ureter. The absorptions powers of streptomycin and penicillin on the renal pelvis were stronger than on the bladder, although not so more than on the seminal vesicles. Streptomycin were better absorbed than penicillin. On the groups of the non-knotted ureter, absorptions were little observed and only few dosis of them were transferred into blood. When hyaluronidase were added to the solutions, antibiotics were more strongly absorbed but they revealed for a sometimes after administrations. Penicillin is influenced stronger than streptomycin to hyaluronidase on the absorptions powers of the renal pelvis. When antibiotics were instillated to the renal pelvis with the degenerated renal tubules caused by knotting of the renal artery for 60-80 minutes, their absorptions were definitely inhibited. These results seem to show that renal tubules have a significant role on the absorptions of renal pelvis of antibiotics.