尿石溶解の研究(第5報) 第I篇:動物実験 第II篇;臨床応用

Abstract

Adult male albino rats were subjected to a suprapubic cystotomy and two small pieces (one is phosphate, the other is oxalate of human urinary calculi) were placed in the urinary bladder of each animal. One of some drugs dissolved in water, 3 0 cc daily was administered trying to dissolve the inserted stone pieces or to inhibit the stone growth. To each animal, moreover, was administered orally 5000 0 U. of dibenzylethylenediamine dipenicillin G once a week and at the same time pH determination of urine was taken place. After 6 weeks the animals were sacrificed the stones being removed and weighed. The data of nearly 13 % of all animals which were infected with urea-splitting organisms and those of so called accessory calculi were discarded from the series. The drugs used are shown as below. 0.4 % sodium aminosulfonate, 0.4 % taurine, 1 chondroitin sulfate, 0.05 Rowatin (Rowa. Wager K. G. of Kologne), 0.4 % ammonium rodanate, 0.2 'Y•z glucosamine, 0.2 (K, d-glucuronic acid, 0.2 % d-glucuronic acid containing 0.05 % Tween 80, 0.2 % d-glucuronic acid containing 0.05 % Rowat in, 0.2 % d-glucuronic acid containing 1 % ammonium chloride, water (control). From the results it has been cleared that d-glucuronic acid is effective for the purpose of dissolution of urinary calculi especially for phosphatic calculi in vivo. To 8 p a t ients of upper urinary calculi were administered 5 g of glucuronolactone or 6-12 drops of Rowatin daily for about two weeks. Another case of upper urinary calculi was treated by both drags.