泌尿器科領域に於ける凝固酵素トロンビンの応用

Abstract

The protective functions of bleeding in our living body are constriction of blood vessels, blood coagulation and coagulation of blood-plasma, and we know that the principle of blood coagulation is the transformation of Fibrinogen to Fibrin. In this transformation, it is obvious that the Thrombin play the most important part, but it has been impossible to clinical application because there is only a Prothrombin in blood-plasma and chemical analysis is very difficult. At present we have obtained a pure Thrombin and tried to bleeding from the bladder in rabbits. As a result of this experimental study, we know that the Thrombin solution to bladder washing is 5u/lcc. In our clinic we applied t u berculosis, cancer, calculus, and papilloma of bladder, and haemorrhagic cystitis to bladder washing. We obtained satisfactory results.