泌尿器科手術に於けるメキサンの使用経験

Abstract

Clinical evaluation of Mexan (methoxamine) has be e n undertaken on 53 cases to combat hypotension caused by spinal anesthesia. Elevation of blood pressure averag e 27.8mmHg (4-54mmHg) from the control levels 5-10minutes after intramuscular injection of Mexan in the operating room prior to s pinal anesthesia. For 40 cases to which 10mgm of intramuscular injection of Mexan were given prior to spinal anesthesia, effects of Mexan on spinal hypotension were found to be either no change or elevation of blood pressure in 20 cases and fall in blood pressure in 20 cases but only 5 cases were injected additional intramuscular or intravenous injection of Mexan. Intramuscular or intravenous injection of Mexan resulted in elevation of blood pressure in these patients whose blood pressure fall due to spinal anesthesia without Mexan injection in 13 cases, in 5 cases is combination of the anesthesia and Mexan injection and in 21 cases companied hypotension during surgical procedure. Generally Mexan did not alter rate of pulse except in few ca s e s. Example of illustrated blood pressure curves are shown. It is presumed that Mexan is a relative longer acting vasopressor because this agent was administered only once or twice during long operative period.