5-Methyl-3-Sulfanilamido-isoxazoleによる尿路感染症の治験

Abstract

Experimental and clinical studies of a new sulfon a m ide, 5-Methyl-3-Sulfanilamido-isoxazole, have been undertaken. Maintenance of the effective concentration of this drug in the blood stream has been found to be relatively longer according to measurement of its concentration in the blood and urinary excretion. This drug has been employed to fourty four patients mainly consisted of acute or chronic cystitis and urethritis and it is found that this drug is as effective as other sulfonamides. Unlike others satisfactory effect can be obtained with doses of 1-2 gm only twice daily and thus frequent administrations are not required. Furthermore no additional fluid and alkalizing therapies are required to prevent acidificaiion of urine. Only side effect encountered was in three out of forty four patients.