尿路結核知見補遺 第IV:篇尿路結核における結核菌培養成績及び薬剤耐性に就て

Abstract

The culture of tubercle bacilli was carried out in 76 c ases of urinary tuberculosis, and the results obtained by culture was compared with that of Ziehl-Neelsen stain. The culture is a more surer way to recognize the tubercle bacilli in urine than microscopic examination of stained preparations. The culture was positive in 28 cases out of 31 control series, and in the chemo-series the positive results were obtained in 25 out of 45 cases. The results show that the length of treatment and the negative cultre is proportionate, but after the long term treatment over three years tubercle bacilli were still found in three out of four cases. Tubercle bacilli could not be isolated in the cases with calix occulsion or ureteral obstruction frequently. Initial resistant strain could not be found in 28 control strains. The incidence of resistant strain and length of treatment is proportionate. Treatment with only one drug and irregular administration promote the incidece of resistant strain, so antibiotics should be administrated in form of combination therapy, and the triple drug therapy is a superior method to reduce the rate of acquisition of resistance to drugs. No tubercle bacilli in urine do not mean the histological healing of ranal lesion.