正常並に病的膀胱壁の病理組織学的研究 主として弾力線維,膠原線維及び筋線維に就いて

Abstract

Distribution and quantitative transition of elastic fibers, c ollagenous fibers and smooth muscle fibers of the bladder of the human being of all ages, especially over age of manhood, at which neoplasms are Haber to develop, were studied and also histopathological studies on the bladder walls in the cases of neoplasms of the bladder or prostatic hypertrophy were performed with special reference to elastic fibers, collagenous fibers and smooth muscle fibers. Stud i es were performed in 64 cases of the normal bladder, 10 cases with neoplasms of the bladder and 14 cases with prostatic hypertrophy. Specimens were obtained from trigonum vesicae, the region aroud orificium ureteris, vertex vesicae, and the region around orificium urethrae internum and histological studies were performed. The results obtained were as follows: (1) According to increase of a g e, it was observed that marked proliferation of elastic fibers being accompanied with proliferation of collagenous fibers and atrophy and disappearance of smooth muscle fibers, especially of those in the innermost muscular layer. (2) Elastic fibers were markedly increased in the region around orificiu m ureteris and in trigonum vesicae. On the contrary, in vertex vesicae increase of elastic fibers was not so marked and both increase of collagenous fibers and atrophy or disappearance of elastic fibers and smooth muscle fibers were scarcely observed. (3) Newly formed elastic fibers were obse r v ed around the basal membrane in several cases. (4) Pathological changes were often observed in the mucous membrane of the bladder of the persons aged over fifty. (5) In the cases of t umors of the bladder, increase of elastic fibers was observed corresponding to age. But elastic fibers were scarcely observel in stroma around the nests of cancer cells where collaginous fibers were increased. (6) In the bladder wall with trabeculae, hypertrophy of smooth muscle fibers was observed and both collagenous fibers and elastic fibers were slightly increased. Above mentioned findings in the bladder wall with trabeculae were not observed in the normal bladder of the persons of the same age. (7) The local increasing of the e lastic fibers of the bladder wall seems to be affected by some factors from the nature of the epithelium of the bladder mucosa.