持続性サルファ剤Binoxinの尿路感染症に対する応用

Abstract

This report deals with clinical research for treatm e nt of urinary tract infections with a long-acting sulfonamide, Sulfadimethoxine (Binoxin). This drug acheaved high plasma concent r a tions within three to six hours and maintained them for at least 24 hours following single oral dosis of 1 and 2 grams. 24 and 48 hours after administration about 24.0-27.0% and 38.0-42.0% of an administrated dose of this drug were recovered in the urine. Sulfadimethoxine was administrated orally t o a healthy adult in dosis of 1 gram the first day followed by 0.5 grams for four successive days, to the second subject in dosis of 1 gram the first day followed by 0.5 grams every twelve hours for four successive days and to the third subject in dosis of 2 grams the first day followed by 1 gram for four successive days. The third administration method was most successfully to let maintain the level on the same level to that of 24 hours after the first administration. Binoxin was used for urinary tract infections containing 5 case s with acute cystitis (1 significantly effective, 3 : effective, 1 poorly effective), 2 cases with chronic cystitis (1 poorly effective, 1 not effective), 1 cases with acute pyelitis (effective), 4 cases with chronic pyelitis (2 effective, 2 not effective) and 6 cases with NGU (1 significantly effective, 4 : effective, 1 : poorly effective).