尿路感染症に対する新持続性サルファ剤メリアン錠の応用経験

Abstract

This report deals with plasma concentration, excr e tion and clinical effect of the new long-acting sulfonamide, 3-(p-amino-benzensulfonamido-2-phenyl-pyrazolM). aintenance of the effective concentration of this drug "Merian'' in the blood stream has been found to have good result on measurement of its concentration in blood and urinary excretion. After oral administration of 1.0 g of this drug, maximum blood level in 6 hours of 8.0 mg/dl has reached and after 24 hours the level has still remained in 5.4m g/dl. It is proved that this drug is a new long-acting sulfonamide. Using to 18 patients with cystit i s , this drug was significantly effective in 15 cases and not so effective in 2 patients, who had chronic cystitis with lower urinary tract complications. Using to 6 cases with pyelitis, in 5 cases remarkable good result was gained. To 6 cases with N.G.U. this drug was very effective. No side effect was encounted.