前立腺癌並びに同肥大症の畢丸に就ての組織学的並びに組織化学的研究 第2報:性ホルモン及び副腎皮質ホルモン投与が睾丸に及ぼす影響についての実験的研究

Abstract

The testicles of white male rabbits which w e ight about 2 kg administrated for 3 weeks synthetic estrogen (Robal 1-2 mg daily. Suron 1-2.5 mg daily), androgen (Enarmon : 2.5 mg daily), corticoids (Cortisone : 12.5 mg daily) were examined histologically and histochemically. The weight of the rabbit testicles decreased markedly when synthetic estrogen or androgen was administrated. The more marked histological and histochemical changes of testicles were observed in the group of the administration of high dosis of estrogen than in the group of small dosis of estrogen. Also, the changes of testicles were almost identical in both group of androgen administration and estrogen. In the cortisone administration, the changes of testicles were almost similar, but relatively slight. In the interstitial cells of Leydig in these rabbits administrated estrogen, androgen and cortisone, any changes were not observed. However, interstitial cell lipids and alkaline phosphatase reaction decreased after the estrogen and androgen administration, but no changes after the cortisone. The 17 ketosteroids in urine decreased after estrogen administration and increased after androgen and cortisone administration. According to the above results, it was presumed that high dosis of the estrogen administration temporarily repressed the androgen secretion from testicles but could not be used in place of castration.