泌尿器科領域に於ける剥離細胞学の研究 II.尿路腫瘍の剥離細胞にっいて

Abstract

The squamous cells in the urine and secretion on 75 genitourinary patients with tumor were stained by means of Papanicolaou's original staining method and Keio's modified method. De t e ctability of tumor cells from the urine of 40 patients with renal-, ureteral-, or bladder tumor was 85.0 per cent positive, 5.0 per cent weak positive and 10.0 per cent negative. Detectability of tumor cells from prostatic fluid was 63.6 per cent positive and 36.4 per cent weak positive in the patients with carcinoma, while that of the patients with sarcoma was totally negative. The detectability in 17 patients with prostatic hypertrophy was 17.6 per cent weak positive with no positive. Furthermore, stump preparation was prepared o n every tumor removed and specimen biopsied, from which more accurate diagnosis was made. Feulgen reaction was performed on 12 cases an d it was found that the reaction was satisfactory supplemental diagnostic measure. Nuclear measurements of the squa m ous cell were done on 34 cases. As a result of study on the basis of their clinical picture and cytology, the greater difference in nuclear size, the stronger was the malignancy. After administration of a nti-cancerous substances and radiation therapy, vacuolation and changes in number and configuration of the nucleus were first appeared, then a certain change appeared in the cytoplasm. The degree of these changes were more significant in those patients who received radiation therapy. When estrogen was administered to the patients with prostatic cancer, appearance of glycogen cells and an increase in squamous cell, especially cornified cells were noted. According to India-ink phagocyte of tumor cell of the patients with bladder tumor, this function was apparently disturbed or none comparing with normal cell.