前立腺癌に対するHonvan錠使用経験

Abstract

Honvan-Tablet (Diaethyl-dioxystilben-diphosphat) h as been administered on 6 patients with prostatic cancer. The drug was found to be markedly effective on 3 cases, effective on 2 cases, and not effective on 1 case. Even though the period of adm i nistration of the drug was too short in the first and second cases to improve the subjective symptoms and the physical findings of the prostate, marked decrease in total serum acid phosphatase, especially prostatic serum acid phosphatase was found in blood biochemical test. Furthermore, marked improvement in cystometric findings in the first case was obtained. Therefore, the authors judged the drug was effective in both the first and second cases. In the third through fifth cases, the administ r ation of the drug was accompanied by castration. The effect of the drug was clinically significant because of loss of subjective symptoms, decrease in consistency of the prostate in the fourth and fifth cases, and histological improvement of the prostate in the fifth case. In the sixth case simple prostatectomy was perfor m ed due to hypertrophied prostate. The prostate was turned out to be cancer according to histological study on the specimen. Castration was immediately performed, which was followed by administration of the drug. However, only small dosis could be administered because of its side effects. Although histological improvement in a part of the prostate was consequently found, increase in consistency of the prostate with bone metastasis and increase in total serum acid phosphatase were resulted. The authors judged the drug was not effective in this case. No side effects of the drug was noticed except compressive feeling of the chest in the second :nd fifth cases. Papilar pigmentation was noticed 12-15 days after the beginning of administration of the drug in all cases.