超薄切片法に依るCondyloma Acuminatumの電子顕微鏡的観察

Abstract

Since Lipschiltz and others have presumed t he virus as a suspicious cause of the condyloma acuminatum, the virus infection theory has been considered as the most probable etiology of the condyloma acuminatum. The author, recently, has studied its fine structure by means of electron-microscope in twenty-five cases. The results are summarized as follows. 1) In only tw o out of the twenty-five cases, the abnormal granules are seen in the cytoplasm of the prickle cell, and are suspicious enough as a virus of 150-250mp in size. 2) In the six cases including the above mentioned two, some changes are noticed in the cytoplasm ; i. e. a relatively non-structural clear change in, the two cases and a vacuole like change in the rest of the four. 3) In all the twenty-five cases, th e stratum corneum is generally edematous and less cornified. 4 ) In the nineteen cases excluding above mentioned six, the prickle cell stroma reveals generally clear structure. 5) The nucleus an d nucleoles of the prickle cell are generally larger and relatively stable. 6) The mitochondria reveals remarkable enlarging deformity and the arrangement of the cristae mitochondriales is rarely in order. 7) The endoplasmic reticulum, Golgi a rea, etc. are relatively less developed. 8) The tonofibril has remarkably decreased in the cells of which c y toplasm revealed the above mentioned degenerations.