慈大式人工腎臓 "Jikei ELECTRO-DIALYZER"の研究 第6報: Salicylate透析に関する実験的研究

Abstract

The artificial kidney first was used in dialysis o f the experimental salicylism by J. J. Abel in 1914. The clinical use of the artificial kidney in salicylism has hitherto been reported in several cases by P. D. Doolan (1951), A. A. Robin (1951), G. E. Schreiner (1955), R. 0. Burns (1958) and A. C. Thomsen (1958). However no report has been seen so far concerning electrodialysis of salicylism. The author carried out a s e ries of in vivo and in vitro experiments on electrodialysis of salicylism with the Jikei electro-dialyzer Model-C. The results are summarized as follows : 1) In vitro experiments, the ratio of efficiency of the ordinary dialysis without electrofiltration and the electro-dialysis was 1 5. 2) In normal dogs the speed of the redu c tion of the blood salicylate concentration was extremly slow. It was 2.3mg/d1/hr. in non- anesthetized dogs and 1.86mg/d1/hr. in anesthetized dogs. 3) In the case of electrodialysis of the dogs with salicylism with 0.1gm/kg of salicylate the average speed of the reduction of the blood salicylate concentration was 17.45mg/dl/ hr. in non-nephrectomized dogs and 15.38mg/d1/hr. in nephrectomized dogs.