睾丸造精機能の研究 第1編: 諸種疾患における睾丸造精機能について

Abstract

Following conclusions were obtained from autopsy, surgery, and surgical specimen on 10 cases of atomic bomb sufferer, 16 cases with generalized disease, 9 cases with prostatic cancer, 21 cases with prostatic hypertrophy, 21 cases with tuberculous epididymitis, 2 cases with simple epididymitis, 20 cases with diseases of the testicle or its adjacent tissue, 11 cases with sexual dysfunction, and 12 cases with sterility. 1) Atomic bomb sufferer, 10 cases : Spermato p oietic dysfunction was found in all 10 cases, among which moderate dysfunction was found in 6 cases, slight dysfunction in 4 cases. However, this dysfunction was rather more extensive than that found in the other diseases. The specific findings in one case were perivascular infiltration of tumor cells. 2) Generalized disease, 16 cases Moderate spermatopoietic dysfunction was f o und in 3 cases and slight dysfunction in 12 cases. The dysfunction was rather severe in the cases with intracranial diseases, cirrhosis of the liver, and leukemia. In a case of pulmonary tuberculosis, although testicular fundings were normal, the tuberculosis was so acute that death ensued. 3) P rostatic cancer, 9 cases Spermatopoietic dysfunction was found in all 9 cases, among which moderate dysfunction was found in 3 cases and slight dysfunction in 6 cases. In these cases, the dysfunction by age was naturally under consideration. The specific findings in this group were proliferation of Leydig's cell in 7 out of 9 cases. 4) Prostatic hypertrophy, 21 cases : Moderate spermatopoietic dys f unction was found in 8 cases, slight dysfunction in 12 cases, and normal function in 1 case. Proliferation of interstitial connective tissue was found in 16 cases. However, proliferation of Leydig's cell was found in few cases in which the proliferation was slight and in most cases there was a tendency to be normal or rather decreased. 5) Tuberculous epididymitis, 21 case s Spermatopoietic dysfunction was found in all 21 cases, among which moderate dysfunction was found in 6 cases and slight dysfunction in 15 cases. Furthermore, the degree of the dysfunction was parallel to changes in the epididymis. In cases with tuberlous formation and cellular infiltration into the interstitial tissue, spermatopoietic function was highly disturbed. 6) Simple epididymitis, 2 cases : Spermatopoietic dysfunction was not found in both cases. Microscopic fundings of the testicle was almost normal comparing with that of tuberculous epididymitis in which clinical findings were identical to simple epididymitis. 7) Diseases of the testicle and its adjacent tissue, 20 cases Sever s p ermatopoietic dysfunction was found in 2 cases, moderate dysfunction in 8 cases. Marked dysfunction was found in the patients with congenital defects, such as micro-orchidia, eunuchoidism, and hypospadia, or hormonal disturbance. 8) Sexual dysfunction, 11 cases : Spermatopoietic dysfunction was found in all 11 cases, among which moderate dysfunction was found in 5 cases, slight dysfunction in 6 cases. It is interesting to note this result from a stand point of etiology of sexual dysfunction. 9) Sterility, 12 cases : Spermatopoietic dysfunction was found in all 12 cases, among which moderate dysfunction was found in 3 cases, slight dysfunction in 9 cases. The specific findings were thickening of the basilar membrane in all cases.