前立腺間質結合織増生へ及ぼす抗男性ホルモン療法の影響についての実験的研究 第1報: 合成発情物質投与，除睾術及び副腎皮質ホルモン投与のラッテ前立腺組織への影響についての生体染色による研究

Abstract

Although it is well known that the antiandrogeni c therapies bring about certain beneficial effect on carcinoma of the prostate, any definite explanation for their mechanism has not yet been given. Nicol et al. ascribed a dominant role therein to a stimulation of the reticulo-endothelial system not only of the prostate but also throughout the whole body. Being interested in this view, the author attempted to estimate in rats the influence of endocrine therapies by means of vital staining findings in their prostates. In rats, prostat e is distinctly divided into five lobes, i.e., ventral, dorsal, lateral, middle and anterior lobes; some differences among these lobes have been confirmed in respesct to the response to endocrine therapies. After some selected fields of each lobe were sketched with drawing apparatus, the areas of acini were measured with a planimeter. The activity of reticuloendothelial system was scrutinized by the counted number of dye-bearing cells in the stroma. The results obtained were as follows : (1) Five lobes of the rat prostate w e re sensitive to the estrogen administration and orchidectomy in the order mentioned above. (2) Cortisone administration resul t e d in a slight fibrosis in dorsal and lateral lobes. (3) In the case of the estrogen admistration and orchidectomy, the number of h i stiocytes in the stroma, especially of the ventral lobe, increased in the early stage, while it gradually decreased accompanied by the hypertrophy of stroma, until there appeared, in place of the histiocytes, an increase of the fibrobrasts, which finally decreased. (4) Following the cortisone administration, the number o f dye-bearing cells of the dorsal and lateral lobes slightly increased in the early stage, and followed by a decrease. (5) From the above results, it may be presumed that the fibrosis of prostate brought about by the endocrine therapies is related to the stimulation of reticulo-endotherial system: there were observed an accumulation of histiocytes, their transformation into fibroblasts and the formation of fibrous tissues.