腎阻血可能限界に対するウレタン誘導体の影響

Abstract

The present authors tried to prevent the developm ent of renal disturbances due to interruption of renal blood flow by administering urethane derivatives before the interruption, in an attempt to combat renal ischemic, hypoxia. By this, apparently the simplest and safest method was given to treat renal ischemic hypoxia which constitutes a main factor for renal dysfunction accompanying certain renal procedures such as partial nephrectomy, renal artery replacement and certain cases of nephrolithotomy, so that the safety of operation may be secured. Unil a t eral nephrectomised rabbits were employed. Renal blood flow was interrupted for 60, 80 and 120 minutes. Forty to 50 minutes before interruption, ethylurethane (EU) was subcutaneously administered at a rate of 0.3-0.5 gm/kg and octylurethane (OU) intraperitoneally 20 mg/kg. Local hypo t h ermia in the renal cortex was kept at 15-22°C (H Group 1) and at 23-30°C (H Group 2). Tests w e re made for survival days, renal function consisting of BUN, GFR (Csts), ERPF (Cpah) and PSP, histopathological findings (HE and Sudan IV staining), renal blood circulation changes (intraaortic black ink filling) and crossed blanching (Gordon & Flasher, 1951). Also the amounts of left renal blood flow in a dog were measured with an electro m agnetic flowmeter immediately after, 24 hours and 48 hours after the blood circulation was interrupted for one hour. The above experi m ents were performed at less than 25°C. Urethane derivatives (EU and OU) intensify a resistan c e against renal ischemic anoxia, allow to prolong the time for interruption and make post-operative renal dysfunction reversible. Their effects are almost equal to those of local hypothermia. OU seems more Pffertive than VET