泌尿器疾患とくに尿路結石症と尿ムコ蛋白に関する研究 第1篇: 尿路結石症その他2～3の泌尿器疾患々者に於ける尿ムコ蛋白,ヘキソース,ヘキソサミン,グルクロン酸及び保護膠質について

Abstract

1) Protective urinary colloids in urolithiasis ge n erally showed an increased activity while the urinary mucoprotein a decrease in some cases of the renal calculi and an increase in the ureteral and vesical calculi. The two substances, which are influenced by nature and property of the urine, showed high levels in such cases as pyuria, hematuria and proteinuria. The mutual relation of urinary mucoprotein and protective urinary colloids could not generally be seen, although in some cases they both showed a marked increase. 2) Effects of administered Various drugs on urinary mucoprote i n and protective urinary colloids were studied. Hyaluronidase, Stronger Neominophagen C, vitamin D2, polyvinylpyrrolidon and glucuronic acid produced an increase of these two substances. 3) In most cases of urolithiasis urinary hexose and hexosami n e generally showed an increase and were esp. pronounced in amounts of these protein-bound components. Glucuronic acid excreted in urine also showed a pronounced increase, but varied in individual cases. 4) Removal of the calculus produced a decrease of urinary mucoprotein and prote c tive urinary colloids in majority of the cases, whereas a decrease of urinary protein-bound hexosamine and a slight increase of urinary hexose occured and glucuronic acid showed an indefinite behavior. It is thought that these substances studied above were influenced by surgical operation, general physical condition, etc. 5) In general the mutual relation between urinary mucoprotein and its protein-bound polysaccharides could not be established, although some showed parallel relatio n. Ratio of protein-bound hexose to hexosamine in normal urine was comparatively constant, while it fluctuated in urine of urolithiasis. 6) Malignant tum o r of the urinary bladder showed a marked increase of these substances. From the results of these investigations, it may be pointed out that protective urinary colloids, urinary mucoprotein and urinary polysaccharides in urine of the urolithiasis, compared with that of normal urine, have shown a fair difference. However, it will still require further investigations, to accknowledge whether these substances may or may not have a special importance as to the pathogenesis of calculus formation.