前立腺の亜鉛に関する臨床的実験的研究

Abstract

Quantitative analysis of Zinc in the normal, hypertrophic , and cancerous prostate of men and in posterior lobe of the prostate of mice to whom castration had been performed or sex hormone had been administered, was carried out and the following results were obtained. 1) Zinc content in the normal prostate averaged 790.2 7/gm, 751.8 7/gm in the hypertrophic prostate. Zinc content in the glandular hypertrophic prostate averaged 887.47 /gm and 390.3 7/gm in the fibrous hypertrophic prostate. 2) Zinc contents were lower than norm a l in fibroush ypertrophic prostate and prostatic cancer. It is more likely in these diseases that prostatic cells are compressed and atrophied by proliferation of interstice or secretory dysfunction of the prostate due to cancerous degeneration of prostatic cell. 3) Effects of adminis t r ation of testosterone propionate and estradiol benzoate upon the prostate of normal mouse were minimal. 4) Zinc content was marked l y reduced a week after castration, though it was not further reduced 2 to 3 weeks after castration. 5) Administration of 5 mg a n d 1 mg of testosterone propionate to the castrated mice caused increase in Zinc content to normal range. However, administrations of estradiol benzoate or 0.1 mg of testosterone propionate did not increase Zinc content. 6) It is likely that prostatic function parallels its Zinc content i n mouse.