前立腺肥大症の組織病理学的研究

Abstract

Step-sections of prostates selected at random from 335 au t o psy cases ranging betweenthe age of 1 month to 90 years were studied histologically and at the same time 6 biopsycases of nodular hyperplasia of prostate were examined under the electron microscope toreveal the following results.1) In general, t h e prostate gland is fully developed by puberty, and degenerativechanges occur after the age of 40.2) The incidence of nodula r hyperplasia was 25.9% (87 out of 335 cases), and theyappear after the age of 40. Their incidence demonstrates a sudden steep curve after theage of 60 (70%).There s eems to be no marked difference between Japan and Western countries as tothe frequency and age distribution of nodular hyperplasia.3) Nodular hyperplasia was classified in t o two types ; primary nodule and genuinenodule. These were subdivided into several types and the transition between them wasdiscussed.4) Those demonstrating periglandular proliferation is considered to be the basic formof primary nodule. Among the 83 cases with genuine nodules, glandular nodules weremost frequently encountered and they occurred in the lateral lobes.5) So called intervesicular nodules and median lobe hyper t r ophy were found in only afew cases. Their histogenesis and histological features were also discussed.6) Electron microscopical observation of nodular hyperplasia revealed the glands tobe composed of several layer of cells ; basal cells, secretory cells and intermediate cells.