新尿路結石溶解剤Renacidinについて

Abstract

In vitro at 37°C, extracted urinary calculi were continuou s ly irrigated at 5-10 drops per minute for 72 hours with 10% and 15% renacidin solutions, as control distilled water and titriplex III (E.D.T.A.) solution. The examined calculi weighed every 6 hours. As the result, phosphate and carbonate stones were markedly disolved with renacidin solutions, whereas oxalate and urate obtained no result. 15% solution was about twice as effective as 10%. Four cases with renal stones were treated with the continuous irrigation of 15% r e nacidin solution at 10-40 drops per minute for 82-218 hours, one of whom had good result. The huge staghorn calculus was dissolved and reduced to finger-tip and pea in size on radiographic appearance. One patient passed majority of small stones after removal of catheters. One of two failures were assigned to the unsatisfactory location of pyelostomy tube. In the other, the stone was urate and in vitro insoluble. As undesirable side effects, th r e e cases suffered from febrile attacks, pain and macroscopic hematuria. Only one patient was free from any complications. The fluctuations in serum phosphorus, N.P.N ., 'electrolytes and PSP test were observed before, during and after the irrigation. We recognized the moderate elevation of N.P.N., the slight of serum P and K and the lowering of PSP test.