協力性性腺刺戟ホルモン製剤, Gonagen-forteの臨床効果に関する研究

Abstract

Gonagen-forte is a mixture of pituitary gonadotropin and chorionic gonadotropin. Comparative studies were first made as to the effects of Gonagen-forte, human chorionic gonadotropin (HCG) alone, pregnant mare serum gonadotropin (PMS) alone, and a mixture of HCG and PMS upon the gonads of the experimentally pituitectomized rats. Gonagen-forte was proved to inhibit atrophy of the testes and adnexa of the pituitectomized rats. It was shown, however, that Gonagen-forte was effective well but not especially compairing with others. Gonagen- f o rte was also clinically used for male infertility, undescended testes and eunuchoidism. Five of 12 male infertility showed increased sperm count, all of two undescended testes improved, but all of two eunuchoidism did not show any change.