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Title: 核酸前駆物質AICA orotate(AICAMIN)による男性不妊の治療
Other Titles: Aica Orotate, a Nucleic Acid Precursor, in the Treatment of Male Sterility
Authors: 森, 昭  KAKEN_name
原, 信二  KAKEN_name
西垣, 定雄  KAKEN_name
長久, 謹三  KAKEN_name
Author's alias: MORI, Akira
HARA, Shinji
NISHIGAKI, Sadao
CHOKYU, Kinzo
Keywords: Imidazoles
Infertility, Male
Nucleic Acids
Orotic Acid
STERILITY, MALE
Issue Date: Aug-1963
Publisher: 京都大学医学部泌尿器科学教室
Journal title: 泌尿器科紀要
Volume: 9
Issue: 8
Start page: 460
End page: 465
Abstract: AICA orotate (AICAMIN), a nucleic acid precursor, was u sed for the treatment of male sterility. Therapy with AICAMIN in doses of 600 mg/day administered orally was carried out for 4-10 weeks. 1. Of 10 cases of oligozoospermia, 6 showed an increase in sperm counts and 4 were irresponsive to the treatment. Sperm motility was slightly improved in 6 cases. 2. In all 4 cases of azoospermia treated, spermia did not appear in the seminal fluid. 3. Of the 4 cases of necrozoospermia and asthenozoospermia, 1 showed a m oderate increase in motility of the sperm and 3 were irresponsive to the treatment. 4. Five cases of oligozoospermia were treated with a com bination of AICAMIN and gonadotropic hormone preparations. The result was that the number of the sperm increased in all cases. The effect of this agent was remarkable especially in 2 cases. 5. No changes were observed in urinary 17-KS, urinary gonadotropin , and plasma cholesterol values before and after the administration of AICAMIN.
URI: http://hdl.handle.net/2433/112457
PubMed ID: 14051178
Appears in Collections:Vol.9 No.8

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