膀胱尿管逆流を合併した慢性腎不全とCytochrome C

Abstract

Our radiological and pharmacological studies on the pathogenesis of vesi c oureteral reflux in traumatic paraplegics for the past five years indicated that the functional and metabolic abnormalities in the musculature of the ureter play a more important role than the anatomical changes at the ureterovesical junction. Six cases of the persistent vesicoureteral reflux have been improved by the administration of either one of bethanechol chloride, tocopherol and AICA orotate. Five cases of the unimproved vesicoureteral reflux were t reated with cytochrome c, 20 mg daily intravenously, for 20 days. No improvement on vesicoureteral reflux was recognized. However a remarkable radiological improvement of renal function of the hydronephrotic kidney complicated with the complete vesicoureteral reflux was noticed in one out of five. Such results suggest us the possibility of beneficial e'fect of drug treatment, s u ch as cytochrome c, for hydronephrotic atrophy of the kidney, and that the vesicoureteral reflux is not the cause of the progressive renal insufficiency but is a symptom which manifests the functional and organic deterioration of the upper urinary tract.