プリモボランの泌尿科領域における臨床的応用

Abstract

This report deals with the clinical effects of "Primobolan=PMB", a kind of protein anabolic steroid, given either oral or parenteral (Depot) ways to a series of 21 patients with urological diseases. (1) A r emarkable or moderate improvement was obtained on subjective and objective symptoms in almost all cases. (2) The most remarka ble effect was seen especially in patients with wandering kidney, nephritis and nephrosis. (3) The pat i ents of advanced age, cachexia and tuberculosis showed rather less effect. (4) Administration of PMB was made 20 mg daily in the oral use or 100m g De pot every 10 days or every 2 weeks in the parenteral use. It was found that the parenteral administration is more effective than the oral use. (5) All cases showed no harmful si de effects, but one case developed husky voice after prolonged use and other two cases had gastro-intestinal disturbances due to excessive eating. (6) Concerning the purpose of gaining weight, individual differences were seen ac cording to the internal and external conditions. (7) Concerning biochemica l changes of the blood, there were decrease of serum Ca and fluctuation within the normal ranges in values of serum Na, K, protein, NPN and P. A remarkable improvement of erythrocyte sedimentation rate was uniformly demonstrated .