膀胱内圧に対するコリン作働薬の作用に関する実験的研究

Abstract

This study, using the adult female dogs, was c a rried out to observe the effects of the cholinergic drugs to the bladder pressure by tracing the course after denervation. It was proved that bladder sensitivity to cholinergic drug increased after sections of pelvic nerves or hypogastric nerves. Bilateral se c tion of the pelvic nerves : After nerve section, the reaction of pilocarpine to the bladder pressure increased day after day until in 10 days when it reached to the maximal state. Subsequently the reaction showed a gradual decline for the period of 6 months with a final one being as same as the pre-operated state. Bilateral section of the hypogastric nerves : One month after nerve section, reaction of pilocarpine to the bladder pressure became slightly stronger than normal but in 3 monthes the reaction returned to the previous state. Bilateral section of the pelvic and hypogastric nerves : Reaction of pilocarpine traced the same course as reaction of bilateral pelvic nerve section. Atropine depressed the bladder pressure raised b y pilocarpine both in normal and in such bladder having hypersensitivity to pilocarpine.