尿路感染菌の薬剤耐性

Abstract

Emergence of drug resistance has been observed frequently in the urinary tract infections , and the importance of proper choice of antimicrobic agents has been repeatedly stressed for its treatment. Clinically it seems, however, to be most important to eradicate the drug resistance purposefully. Chlormerodrin reported by Seneca et al. is the only one for its purpose. Considerations based on the long term examinations of drug sensitivity of bacteria infected in the urinary tract of the chronic traumatic paraplegics in our hospital suggest that the intravenous administration of urea 30-60 g daily is far more effective than chlormerodrin to eradicate the drug resistance of bacteria infected in the urinary tract, at least clinically. The role of urea in urine on the pathogenesis of urinary tract infectio n and on the emergence and eradication of drug resistance should be evaluated bacteriologically and clinically in future.