泌尿器外科領域におけるCyanoacrylate系接着剤の研究 第2報: 腎固定術への応用

Abstract

A series of 29 male albino rats, weighed about 150 grain s , was subjected to be operated on to reach the kidney transperitoneally. A drop of a-cyanoacrylate monomer was applied on the surface of the left kidney in 14 of them while Z-form suture with catgut it 0 was made in 15 of them to fix the kidney with surrounding tissues. The right kidney of each animal was performed exposure only and reserved as control. In the group used a-cyanoacrylate monomer, 5, 5 and 4 animals were killed at 1, 3, and 6 weeks after operation respectively, whereas in the group used catgut, 5, 5, 3 and 2 animals were killed at 1, 3, 6 and 8 weeks after operation respectively. Histological examinations were performed in each anim al. In the group used catgut, all showed retaining catgut with foreign body reactions throughout the observation period of 8 weeks. However, in the group used a-cyanoacrylate monomer, inflammatory picture was scarcely seen after 3 weeks and showed almost no difference to the controls. Four patients with right nephroptosis (3 unilateral nephroptosis an d 1 right nephroptosis accompanied with left pyelonephritic contracted kidney with hypertention) were operated on right nephropexy (after left nephrectomy for the last case) using a-cyanoacrylate monomer. The nephropexy was achieved by adhering the posterior surface of the kidney to the M. quadratus lumborum with a-cyanoacrylate monomer. The results of operation and the postoperative course are q u ite favorable and no sub jective and objective side effect was encountered.